Surgery May Benefit Women With Two Types Of Urinary Incontinence, Study Says

Surgery for stress urinary incontinence (leaking that occurs with a cough or sneeze) improves symptoms of another form of incontinence, called urgency urinary incontinence, in women who have both types, according to a study supported by the National Institutes of Health.

The findings challenge current treatment guidelines, which suggest that the surgery may worsen urgency urinary incontinence in women with both forms, also called mixed urinary incontinence. The study appears in the Journal of the American Medical Association.

Funding was provided by NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and

Office of Research on Women's Health.

"Women with mixed urinary incontinence may have more bothersome symptoms than women with either stress or urgency urinary incontinence alone," said Donna

Mazloomdoost, M.D., study author and program director of the NICHD Pelvic Floor Disorders Network. "The

findings show promise in treating a condition that can be hard to manage under existing practices."

Roughly one-third to one-half of all women with urinary incontinence have mixed urinary incontinence. Urgency urinary incontinence results from the spontaneous contraction of bladder muscles, leading to a strong and sudden need to urinate. Stress urinary incontinence occurs when urine leaks out after abdominal pressure increases following a sneeze, cough, laugh or movement, which squeezes the bladder.

Standard treatment guidelines for mixed urinary incontinence often involve treating the two forms of incontinence independently. Urgency urinary incontinence often is first treated with behavioral techniques, such as trying to delay urinating for a brief period after feeling the urge, reducing liquid consumption, exercises to strengthen muscles around the bladder (involving pelvic floor physical therapy) and with medication. Surgery

is not usually recommended early on.

Stress incontinence can also

be treated with exercises, and many women experience symptom improvement. However, in women who do not improve or opt out of the exercises, surgery may

be offered.

The Effects of Surgical Treatment Enhanced with Exercise for Mixed Urinary Incontinence (ESTEEM) study is a randomized clinical trial that recruited 480 women with mixed urinary incontinence at centers across the United States. All participants underwent

mid-urethral sling surgery, a well-established method that places a thin strip of mesh under the urethra;

this helps prevent urine from leaking out during

an exertion, such as a sneeze or cough.

Participants were randomized to surgery alone or surgery with behavioral and pelvic floor muscle therapy, which included six visits with a trained health professional.

They were followed for one year.

The women responded to a questionnaire, the urogenital distress inventory (UDI), which inquired about urinary symptoms.

Symptoms are ranked

from 0-300 points, depending on severity. They also responded to surveys on quality of life and perceptions of surgical success.

The study team found that both groups had significant improvements in their incontinence symptoms after surgery. The average UDI score for the surgery alone group was 176.8 before surgery and 40.3 a year after surgery;

for the surgery and therapy combined

group, the UDI score dropped from 178.0 to 33.8. According to the researchers, because the post-treatment UDI scores between the two groups did not differ

greatly, adding behavioral and pelvic floor muscle therapy to the treatment may not result in better clinical outcomes.

However, the study team

did find differences in other self-reported outcomes. The combined surgery and physical therapy group had fewer instances of incontinence a year after surgery and were less likely to receive additional treatment for urinary tract symptoms, suggesting they had more quality of life improvement than the surgery alone group.

"Current practice guidelines may be unnecessarily delaying surgery for women with mixed urinary incontinence," said Vivian W. Sung, M.D., M.P.H., the study's lead author and a professor at the Warren Alpert Medical School of Brown University in Providence, Rhode Island. "We

hope these findings will improve how patients

are counseled and treated."

The researchers called for additional research to identify which patients with mixed urinary incontinence are at risk for continued symptoms after surgery and to identify effective treatments for them.