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Smoke billows following Israeli bombardment near Deir al-Balah in the central Gaza Strip AFP

The Israeli army targeted four cities in the occupied West Bank on Wednesday, launching a major new operation alongside its 10-month-old war in Gaza.

Violence has surged in the West Bank during the Gaza conflict sparked by Islamist group Hamas's unprecedented October 7 attacks on Israel.

The war has killed more than 40,000 people in Gaza, according to the Hamas-run territory's health ministry.

It has also caused widespread destruction in the Palestinian territory, displaced nearly all of its 2.4 million people at least once and triggered a humanitarian crisis.

In the West Bank in the early hours of Wednesday, the Israeli military launched a series of coordinated raids across four cities -- Jenin, Nablus, Tubas and Tulkarem.

The army said it was carrying out a "counter-terrorism operation".

The operation, which involved air strikes, ground forces and bulldozers, claimed the lives of at least 10 people, the Palestinian Red Crescent said.

They included two Palestinians killed in Jenin, four in a strike on a car in a nearby village and four more in a refugee camp near Tubas, said its spokesman, Ahmed Jibril.

Fifteen others were wounded, he said.

The Israeli army said it had killed nine Palestinian "terrorists" in its ongoing operation.

Foreign Minster Israel Katz said the military was "operating in full force since last night" in a bid to "dismantle Iranian-Islamic terror infrastructure".

In a post on X, he accused Iran, Israel's main foe in the region, of seeking to "establish an eastern front against Israel" based on the "model" for Gaza and Lebanon, where it backs Hamas and Hezbollah, respectively.

"We must address this threat with the same determination used against terror infrastructures in Gaza, including temporary evacuation of residents and any necessary measures," he said.

"This is a war, and we must win it."

Since Hamas's October 7 attack, Israeli troops or settlers have killed more than 650 Palestinians in the West Bank, according to an AFP tally based on Palestinian health ministry figures.

During the same period, at least 19 Israelis have been killed in Palestinian attacks, according to Israeli officials.

But while Israeli military operations have become a daily occurrence in the West Bank, occupied by Israel since 1967, it is rare for them to be carried out in multiple cities simultaneously.

In recent weeks, Israeli operations in the West Bank have focused on the north of the territory, where armed groups fighting against Israel are particularly active.

The latest operation comes two days after Israel said it carried out an air strike on the West Bank that the Palestinian Authority reported killed five people.

The Israeli army confirmed the five deaths on Wednesday and said the strike hit a structure "used by the terrorists to conduct terrorist activity and harm (Israeli) soldiers operating in the area".

It identified one of the dead as Jibril Jasan Ismail Jibril, who was released in November as part of the only Gaza truce so far, in November.

Last week, the army announced it had killed a senior Palestinian militant in Lebanon, accusing him of "directing attacks and smuggling weapons" to the West Bank and collaborating with Iranian forces.

"With this aggression, which aims to transfer the weight of the conflict to the occupied West Bank, the occupier wants to impose a new state of affairs on the ground to annex the West Bank," the statement said.

Hamas, whose popularity has soared in the West Bank since the start of the Gaza war, late Tuesday reiterated its call for Palestinians in the territory to "rise up".

Its statement came in response to comments by far-right Israeli National Security Minister Itamar Ben Gvir, who said this week he would build a synagogue at Jerusalem's flashpoint Al-Aqsa mosque compound if he could.

Ben Gvir, a settler himself, has openly called for the annexation of the West Bank.

Hamas's October 7 attack resulted in the deaths of 1,199 people, mostly civilians, according to an AFP tally based on Israeli official figures.

Israel's retaliatory military campaign since then has killed at least 40,534 people in Gaza, according to the territory's health ministry. The UN rights office says most of the dead are women and children.

A source with knowledge of Gaza ceasefire talks said on Wednesday that an Israeli delegation arrived in Doha for "technical-level" discussions with mediators on a truce and hostage-prisoner exchange.